| dc.contributor | | en-US |
| dc.creator | Rivera, Augusto | |
| dc.creator | Miranda-Carvajal, Ingrid | |
| dc.creator | Ríos-Motta, Jaime | |
| dc.date | 2018-06-25 | |
| dc.date.accessioned | 2019-04-16T16:42:42Z | |
| dc.date.available | 2019-04-16T16:42:42Z | |
| dc.identifier | https://www.jcchems.com/index.php/JCCHEMS/article/view/678 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/42310 | |
| dc.description | A series of 2,2’-(5-hydroxydihydropyrimidine-1,3(2H,4H)-diyl)bis-(methylene)-disubstitutedphenols was synthesized by using a Mannich-type reaction between 1,3-diaminopropan-2-ol, paraformaldehyde and substituted phenols. These previously unreported compounds were separated from the reaction mixture by column chromatography (CC) in highly pure form with a 29%-91% yield. The effect of intramolecular hydrogen bonding on the conformation of 5-hydroxyhexahydropyrimidines has been studied. Our results show that the presence of hydroxyl groups can strongly influence the stereoelectronic relationships in the six-membered heterocyclic ring. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedad Chilena de Química | en-US |
| dc.relation | https://www.jcchems.com/index.php/JCCHEMS/article/view/678/236 | |
| dc.rights | Copyright (c) 2018 Journal of the Chilean Chemical Society | en-US |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0 | en-US |
| dc.source | Journal of the Chilean Chemical Society; Vol 63, No 2 (2018): Journal of the Chilean Chemical Society | en-US |
| dc.source | 0717-9707 | |
| dc.subject | hexahydropyrimidine; Mannich bases; hydrogen bonding; conformational preference | en-US |
| dc.title | SYNTHESIS OF 5-HYDROXYDIHYDROPYRIMIDINE DERIVATIVES AND THE INFLUENCE OF INTRAMOLECULAR HYDROGEN BONDING ON THEIR NMR PROPERTIES AND CONFORMATIONAL PREFERENCES OF THE HYDROXYL GROUP | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | | en-US |
