| dc.contributor | | en-US |
| dc.creator | Askari Rizvi, Faheem | |
| dc.creator | Raza Naqvi, Syed Ali | |
| dc.creator | Mehdi, Muhammad | |
| dc.creator | Roohi, Samina | |
| dc.creator | Fawad Zahoor, Ameer | |
| dc.creator | Khan, Zulfiqar Ali | |
| dc.creator | Sohaib, Muhammad | |
| dc.creator | Rasheed, Rashid | |
| dc.date | 2017-06-05 | |
| dc.date.accessioned | 2019-04-16T16:42:44Z | |
| dc.date.available | 2019-04-16T16:42:44Z | |
| dc.identifier | https://www.jcchems.com/index.php/JCCHEMS/article/view/145 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/42333 | |
| dc.description | In present study synthesis of 99mTc-triamcinolone acetonide (99mTc-TA) complex and its stability using set of quality control parameters such as ligand concentration, reducing agent concentration, pH, temperature and reaction time was assessed. 99mTc-TA complex was characterized in terms of percent (%) yield, stability in saline and serum using chromatographic procedures. Radiochemically the 99mTc-TA complex was found quite stable in saline and serum. After 30 min of reaction the complex showed maximum radiochemical yield of 96.32% which decreased to 96.25 % after 4 h incubation period. In serum, the % yield of radiochemical was remained same up to 2 h which decreased to 93.5% at 24 h time point. Normal biodistribution pattern in Sprague-Dawley rats revealed liver, stomach and kidneys as areas of high 99mTc-TA complex uptake (8.44 ± 1.32, 8.75 ± 1.03 and 12.67 ± 1.21%, respectively) at 1 h post injection time point. Scintigraphy of 99mTc-TA in rabbits showed similar eco as observed in biodistribution study. Based on the promising results obtained in context of in vitro and in vivo stability and biodistribution, 99mTc-TA complex could be further studied to identify the inflammation based diseases. | en-US |
| dc.format | application/pdf | |
| dc.language | eng | |
| dc.publisher | Sociedad Chilena de Química | en-US |
| dc.relation | https://www.jcchems.com/index.php/JCCHEMS/article/view/145/124 | |
| dc.rights | Copyright (c) 2017 Faheem Askari Rizvi, Syed Ali Raza Naqvi, Muhammad Mehdi, Samina Roohi, Ameer Fawad Zahoor, Zulfiqar Ali Khan, Muhammad Sohaib, Rashid Rasheed | en-US |
| dc.rights | http://creativecommons.org/licenses/by-nc-sa/4.0 | en-US |
| dc.source | Journal of the Chilean Chemical Society; Vol 62, No 1 (2017): Journal of the Chilean Chemical Society | en-US |
| dc.source | 0717-9707 | |
| dc.subject | 99mTc-Triamcinolone; Electrophoresis; Biodistribution study; Scintigraphy of Rabbits; Serum Stability | en-US |
| dc.title | SYNTHESIS, QUALITY CONTROL AND BIODISTRIBUTION OF TECHNEIUM-99M TRIAMCINOLONE ACETONIDE (99mTc-TA) COMPLEX: AN INFLAMMATION TRACER AGENT | en-US |
| dc.type | info:eu-repo/semantics/article | |
| dc.type | info:eu-repo/semantics/publishedVersion | |
| dc.type | | en-US |
