SECONDARY METABOLITES FROM PACHYSTROMA LONGIFOLIUM (NEES) I. M. JOHNST (EUPHORBIACEAE) AND EVALUATION OF ITS EXTRACTS AS CATHEPSINS INHIBITORS
Author
Galvão, Dayane de Cássia
Torres Moraes, Carolina
Pinheiro Borges, Bárbara Juliana
Cavalcante Cardoso, Weverson
de Andrade, Jean Paulo
Mitsuo Takahashi, Pedro
Vieira, Paulo Cezar
Borges, Warley de Souza
Abstract
In this work, four secondary metabolites were isolated from leaves of Pachystroma longifolium (Euphorbiaceae): loliolide, gallic acid, methyl protocatechuate and ethyl gallate. Their structures were established by physical and spectroscopic methods. The extracts of P. longifolium and the purified compounds were tested as cathepsins inhibitors and the extracts were active.