The method of synthesis and the arsenic removal properties of ion-exchange resins based on N-methyl-D-glucamine and trimethylammonium groups are presented. The N-methyl-D-glucamine based monomer was synthesized by the reaction of 4-vinyl benzyl chloride with N-methyl-D-glucamine, along with the use of N,N-methylene-bis-acrylamide as a crosslinker reagent for polymerization. In addition, poly(4-vinylbenzyl)trimethylammonium was synthesized. Arsenate sorption studies were conducted and the pH effect, kinetics, sorption capacity, and elution performance were studied. The experimental data were fitted to kinetic models, such as the pseudo-first order and pseudo-second order models. The pseudo-second order model exhibited the best correlation with the experimental data. The Langmuir and Freundlich isotherms were fitted to the experimental data, and the Freundlich isotherm exhibited the best fit.