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pH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGEL

dc.contributoren-US
dc.creatorde Vasconcelos, Aécio B. P.
dc.creatorSilva, Wagner E.
dc.creatorBelian, Mônica F.
dc.date2018-02-09
dc.date.accessioned2019-04-16T16:43:09Z
dc.date.available2019-04-16T16:43:09Z
dc.identifierhttps://www.jcchems.com/index.php/JCCHEMS/article/view/461
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/42502
dc.descriptionIn this work, a matrix based on silica xerogel, synthesized from TEOS, water, ibuprofen (as template) and acetic acid at room temperature, was used for ibuprofen (IBF) incorporation, aiming to create a drug delivery system capable of releasing this compound under a basic pH condition (considering desirable and optimal release in the intestines). The IBF release was checked at different pH values (ranging from 2 to 8), using appropriate buffered solutions. After observing the IBF release performance from the silica xerogel and its dependence on the pH, the same matrix containing IBF was submitted to a novel assay, using only a pH 7 buffered solution as the best way to check the chronological release. This was carried out at 1, 2, 5 and 10 minutes to determine aliquot removal, as well as IBF concentration at each elapsed period.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttps://www.jcchems.com/index.php/JCCHEMS/article/view/461/193
dc.rightsCopyright (c) 2018 Journal of the Chilean Chemical Societyen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 62, No 4 (2017): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.subjectsilica xerogel; pH-dependent release; ibuprofenen-US
dc.titlepH DEPENDENT DRUG DELIVERY BASED ON SILICA XEROGELen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeen-US


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