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EFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRIMIDINES

dc.contributoren-US
dc.creatorKhatri, Taslimahemad T.
dc.creatorShah, Viresh H.
dc.date2017-06-05
dc.date.accessioned2019-04-16T16:43:10Z
dc.date.available2019-04-16T16:43:10Z
dc.identifierhttps://www.jcchems.com/index.php/JCCHEMS/article/view/147
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/42505
dc.descriptionA series of novel 2-amino-3-cyanothiophenes (2a-2j) were synthesized using heterogeneous base (K2CO3) supported Gewald reaction. Cyclization of 2a-j with formamide and urea in conventional heating as well as microwave irradiation gave thieno[2,3-d]pyrimidines (3a-3j) and thieno[2,3-d]pyrimidin-2(1H)- ones(4a-4j) respectively. The reaction rates were faster and yields were higher in the microwave conditions. The structures of the compounds were confirmed with elemental analysis, mass spectral analysis, FTIR, 1H NMR and 13C NMR techniques. All the synthesized compounds were subjected to antimicrobial activity (MIC) in vitro by broth dilution method and exhibited a moderate antimicrobial activity. en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttps://www.jcchems.com/index.php/JCCHEMS/article/view/147/126
dc.rightsCopyright (c) 2017 Taslimahemad T. Khatri, Viresh H. Shahen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 62, No 1 (2017): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.subjectGewald reaction; Thieno[2,3-d]pyrimidines; Thieno[2,3-d]pyrimidin-2(1H)-ones; Antimicrobial activityen-US
dc.titleEFFECTIVE MICROWAVE SYNTHESIS OF BIOACTIVE THIENO[2,3-d]PYRIMIDINESen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeen-US


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