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dc.contributoren-US
dc.creatorPotluri, Haritha
dc.creatorRao Battula, Sreenivasa
dc.creatorYeturu, Sunandamma
dc.date2017-06-16
dc.date.accessioned2019-04-16T16:43:10Z
dc.date.available2019-04-16T16:43:10Z
dc.identifierhttps://www.jcchems.com/index.php/JCCHEMS/article/view/192
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/42514
dc.descriptionA simple and precise stability indicating RP-HPLC method was developed for simultaneous analysis of drug nortriptyline and pregabalin using BDS (250mm x 4.6 mm, 5m) C18 column at 210 nm of UV detection. Perchloric acid (0.1%) and acetonitrile in the ratio of 55:45 was used as the mobile phase with a flow rate of 1.0 ml/min and linearity response was established over the concentration range of 5-30 μg/ml for nortriptyline and 37.5-225 μg/ml for pregabalin. The active pharmaceutical ingredients recovered for nortriptyline and pregabalin are in the range of 100.60-101.65% and 100.59-101.74% respectively. The method was validated and was found to be stability indicating and can be successfully utilized for the quantitative analysis of pharmaceutical tablet dosage formulations containing nortriptyline and pregabalin.en-US
dc.formatapplication/pdf
dc.languageeng
dc.publisherSociedad Chilena de Químicaen-US
dc.relationhttps://www.jcchems.com/index.php/JCCHEMS/article/view/192/154
dc.rightsCopyright (c) 2017 Haritha Potluri, Sreenivasa Rao Battula, Sunandamma Yeturuen-US
dc.rightshttp://creativecommons.org/licenses/by-nc-sa/4.0en-US
dc.sourceJournal of the Chilean Chemical Society; Vol 62, No 2 (2017): Journal of the Chilean Chemical Societyen-US
dc.source0717-9707
dc.subjectNortriptyline; Pregabalin; HPLC; Stability indicating; Validationen-US
dc.titleVALIDATED STABILITY INDICATING RP-HPLC METHOD FOR SIMULTANEOUS DETERMINATION OF NORTRIPTYLINE AND PREGABALIN IN BULK AND COMBINED DOSAGE FORMULATIONSen-US
dc.typeinfo:eu-repo/semantics/article
dc.typeinfo:eu-repo/semantics/publishedVersion
dc.typeen-US


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