During routine dissection in the Department of Anatomy following anatomical variations of phrenic nerve were observed on right side in the neck region of a middle aged cadaver. The phrenic nerve in its early course close to its origin was giving a communicating branch to C5 root of brachial plexus and at the level of the root of neck just before entering the thorax, the phrenic nerve was placed anterior to the subclavian vein. This unique case of phrenic nerve variation gains tremendous importance in context of subclavian vein cannulation, implanted venous access portals, and supraclavicular nerve block for regional anesthesia