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  • International Journal of Morphology
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  • Sociedad Chilena de Anatomía
  • International Journal of Morphology
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Regulation of the Bone Healing Process by Hormones

Author
Issa,Joáo Paulo Mardegan

Tiossi,Rodrigo

Mello,Amaro Sergio da Silva

Iyomasa,Mamie Mizusaki

Full text
https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200025
Abstract
The skeleton has several important functions, such as structural functions that provide mobility, support, and protection for the body. It also has an important function as a reservoir for calcium and phosphorus. The aim of this article is to show the principal hormones that are involved with the bone healing process. In this article, it will be pointed the mineral homeostatic mechanisms in the skeleton, controlled by the calcium-regulating hormones: parathyroid hormone (PTH) that maintains the normal extracellular calcium levels by enhancing osteoclastic bone resorption and liberating calcium from the adult skeleton; estrogen, considering that both osteoblasts and osteoclasts express estrogen receptors, it is reasonable to assume that the effects of estrogen on skeletal remodeling could be caused, at least partly, by a direct effect on bone cells; androgen with important functions on the adult male phenotype, anabolic actions on skeleton, muscle and bone, including the effects of their metabolism in diverse tissues; and steroids that inhibit the synthesis of proteins, collagen, and proteoglycans in articular cartilage, and inactivate vitamin D, limiting calcium absorption by the gastrointestinal tract, and increasing the urinary excretion of calcium, they also inhibit the release of growth hormone, which further decreases soft tissue and bone repair and lead to a decrease in bone, ligament, and tendon strength
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Discipline
Artes, Arquitectura y UrbanismoCiencias Agrarias, Forestales y VeterinariasCiencias Exactas y NaturalesCiencias SocialesDerechoEconomía y AdministraciónFilosofía y HumanidadesIngenieríaMedicinaMultidisciplinarias
Institutions
Universidad de ChileUniversidad Católica de ChileUniversidad de Santiago de ChileUniversidad de ConcepciónUniversidad Austral de ChileUniversidad Católica de ValparaísoUniversidad del Bio BioUniversidad de ValparaísoUniversidad Católica del Nortemore

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