| dc.creator | Herrera,Christian L | |
| dc.creator | Jaramillo,Priscilla C | |
| dc.creator | Lanas,Fernando | |
| dc.creator | Salazar,Luis A | |
| dc.date | 2007-06-01 | |
| dc.date.accessioned | 2019-04-25T12:34:39Z | |
| dc.date.available | 2019-04-25T12:34:39Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200031 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/59584 | |
| dc.description | The platelet endothelial cell adhesion molecule-1 (PECAM-1), a 130-kDa membrane glycoprotein, is expressed on the surface of monocytes, some T-lymphocyte subsets, neutrophils, platelets and endothelial cells. PECAM-1 plays a key role in the transendothelial migration of circulating leukocytes during vascular inflammation. The aim of the present investigation was to evaluate the association between the C373G polymorphism of the PECAM-1 gene and coronary artery disease in Chilean subjects. A total of 220 individuals were investigated (112 cases and 108 controls). The presence of coronary artery disease was confirmed by angiography (Stenosis >70%). The C373G polymorphism was detected by polymerase chain reaction followed enzymatic restriction. The genotype frequencies were in agreement with those predicted by the Hardy-Weinberg equilibrium in both groups. The genotype distribution and the relative alíele frequencies for C373G polymorphism of the PECAM-1 gene were similar between cases and controls (P= 0.820 and P= 0.739, respectively). Moreover, the OR associated with the mutated G alíele was 0.92 (C.I. 95%, 0.54 - 1.57; P=NS). In summary, our study showed that C373G polymorphism of the PECAM-1 gene is not associated with coronary artery disease in the population analyzed | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Anatomía | |
| dc.relation | 10.4067/S0717-95022007000200031 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | International Journal of Morphology v.25 n.2 2007 | |
| dc.subject | Aterosclerosis | |
| dc.subject | PECAM-1 | |
| dc.subject | Polymorphism | |
| dc.title | Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls | |
