| dc.creator | Guzmán,Neftalí | |
| dc.creator | Erices,Leonardo | |
| dc.creator | Valdés,Patricio | |
| dc.creator | Salazar,Luis A | |
| dc.date | 2007-12-01 | |
| dc.date.accessioned | 2019-04-25T12:34:51Z | |
| dc.date.available | 2019-04-25T12:34:51Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000400030 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/59645 | |
| dc.description | The 34C>G (Prol2Ala) polymorphic variant of the peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) gene has been associated with polycystic ovary syndrome (PCOS). However, the results between populations are contradictory. Thus, in the present study was investigated the possible association between 34C>G polymorphism at the PPAR-γ2 gene and PCOS in Chilean women. A total of 50 unrelated women (29.1 + 8.1 years) with diagnosis of PCOS and 75 healthy controls (29.3+ 9.3 years) were included in this study. Serum lipids, glucose and uric acid levels were determined by enzymatic-colorimetric methods. The 34C>G variant in the PPAR-γ2 gene was analyzed by PCR-RFLP. Women with PCOS exhibited a higher levels of glucose, total cholesterol, triglycerides, LDL-C and uric acid, and lower HDL-C levels than controls (p <0.05). The frequency of the 34G alíele was 9% in PCOS patients and 12% in control women (p = 0.589). The odds ratio for PCOS associated with 34G alíele was 0.73 (95% CI = 0.31 - 1.69) confirming the absence of association. We conclude that the 34C>G polymorphism of the PPAR-γ2 gene is not related to PCOS in Chilean women | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad Chilena de Anatomía | |
| dc.relation | 10.4067/S0717-95022007000400030 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | International Journal of Morphology v.25 n.4 2007 | |
| dc.subject | Polycystic ovary syndrome | |
| dc.subject | Peroxime proliferator-activated receptor | |
| dc.subject | Prol2Ala polymorphism | |
| dc.title | A Common 34C>G Variant at the Peroxisome Proliferator-Activated Receptor γ2- Gene in Chilean Women with Polycystic Ovary Syndrome and Controls | |
