The adhesive systems are responsible for an efficient union between teeth and resin, resulting in a longevity restoration. They are organic molecules di or multifunctional that contain reactive groups that interact with dentin and with the resin monomer of composite resin. The adhesive systems are characterized by wet adhesion, which is a result of presence of hidrophylics radicals in their compositions, to promote a better bond and the best properties of the adhesion. Adhesive systems may use two different strategies to interact with the dental structure: total-etching and self-etching technique. The total-etching systems require a conditioning, a rinsing and a priming step in order to allow involvement of collagen fibers by the resin monomers and the formation of the so-called ‘hybrid layer’. The total-etching promotes the cleaning of dentin, also promotes superficial demineralization and delivers collagen fibrils to participate of an interface union mechanism teeth/ adhesive system/restorative material. Self-etching adhesive systems are characterized by demineralization and infiltration of resin monomers simultaneously. This technique is attractive because reduced sensitivity associated with retaining the smear layer and smear plugs, thereby, minimize the possibility of inadvertent contamination of the bonding surface with dentinal surface through dentinal fluid transudate.