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  • International Journal of Morphology
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Gentamicin Induces Renal Morphopathology in Wistar Rats

Author
de Souza,Vanessa Barboza

Oliveira,Rodrigo Fagundes L. de

Lucena,Hévio Freitas de

Ferreira,Aurigena A. A

Guerra,Gerlane Coelho Bernardo

Freitas,Maria de Lourdes

Queiroz,Karla Cristiane de Souza

de Araújo Júnior,Raimundo F

Full text
https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0717-95022009000100011
Abstract
Due to its prominent role in major excretory pathways, the kidney is particularly sensitive especially to toxicity for antimicrobials drugs. Storage of these drugs in the renal cortex, their effect on renal cells, have consequences on the renal function, and then reabsorbed by renal tubules induce nephrotixicity. Our objective was to show the renal morphopatological alterations induced by gentamicin through the histochemical methods of routine periodic acid de Schiff (PAS) staining and imunohistochemical staining for the expression of the protein P53, which is considered as a marker for cellular apoptosis. This allows the early detection of tubular lesions. The renal morphopathologic findings were cell apoptosis, basal membrane interruption, mesangial proliferation cells, decreased Bowman's space. This result clearly shows that gentamicin administration induces renal morphopatological alterations.
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Discipline
Artes, Arquitectura y UrbanismoCiencias Agrarias, Forestales y VeterinariasCiencias Exactas y NaturalesCiencias SocialesDerechoEconomía y AdministraciónFilosofía y HumanidadesIngenieríaMedicinaMultidisciplinarias
Institutions
Universidad de ChileUniversidad Católica de ChileUniversidad de Santiago de ChileUniversidad de ConcepciónUniversidad Austral de ChileUniversidad Católica de ValparaísoUniversidad del Bio BioUniversidad de ValparaísoUniversidad Católica del Nortemore

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