In the European academic and institutional debate, interoperability is predominantly seen as a means to enable public administrations to collaborate within Members State and across borders. The article presents a conceptual framework for ICT-enabled governance and analyses the role of interoperability in this regard. The article makes a specific reference to the exploratory research project carried out by the Information Society Unit of the Institute for Prospective Technological Studies (IPTS) of the European Commission’s Joint Research Centre on emerging ICT-enabled governance models in EU cities (EXPGOV). The aim of this project is to study the interplay between ICTs and governance processes at city level and formulate an interdisciplinary framework to assess the various dynamics emerging from the application of ICT-enabled service innovations in European cities. In this regard, the conceptual framework proposed in this article results from an action research perspective and investigation of e-governance experiences carried out in Europe. It aims to elicit the main value drivers that should orient how interoperable systems are implemented, considering the reciprocal influences that occur between these systems and different governance models in their specific context.