Social commerce is doing commerce in a collaborative and participative way, by using social media, through an enterprise interactive interface that enables social interactions. Technologies such as Web 2.0, Cloud Computing and Service Oriented Architecture (SOA) enable social commerce. Yet, a framework for social commerce, putting Enterprise Social Interactions as central entities, would provide a strong business justification for social commerce design and adoption with these enabling technologies. This work first proposes a framework for social commerce-oriented business that captures: (a) three main entities: Enterprise social Interactions, Actors, and Business Processes (and their output: products/services), (b) the relationships between these entities, and (c) the constraints (if any). Then, it focuses on the conceptualization of the key entity, Enterprise Social Interactions, to shape the required enterprise interface that promotes openness, collaboration and participation, which enables the required knowledge emergence and intelligence for the value (co-)creation. A central component of the enterprise technology architecture, we refer to as Enterprise Social Interaction Manager (ESIM) realizes the interface. An example shows how the realization of the ESIM functionalities with Web 2.0, Cloud computing, and SOA enables the different categories of collaborative B2B integration that underlines and backs social commerce.