The aim of this research was to realize new potential wood preservatives against fungal decay, with low environmental impact and well fixed into the wood. Pinus sylvestris L. wood samples were impregnated by silica xerogels functionalized with amino groups able to link copper through coordinative interactions. In this study tetraethoxysilane (TEOS) and 3-aminopropyltriethoxysilane (APTES), in different ratios, and linked with copper or not, were utilized to impregnate wood samples, in order to evaluate the factors responsible for the efficacy against the brown rot Coniophora puteana. The fixation to the wood was evaluated through the leaching procedure (EN 84) and the variation on the effectiveness against this fungus. The sol-gel processes TEOS/APTES, ratio 1:1, with or without copper, leached or not leached, showed a good effectiveness against fungus C. puteana.