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dc.creatorHerrera V,José Miguel
dc.creatorBarriga C,Francisco
dc.creatorHarris D,Paul
dc.creatorRonco M,Ricardo
dc.creatorGarcía B,Cristián
dc.creatorRossi F,Ricardo
dc.date1999-11-01
dc.date.accessioned2019-05-02T21:10:38Z
dc.date.available2019-05-02T21:10:38Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98871999001100009
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/81011
dc.descriptionBackground: Malignant hepatic tumors (Mht) are rare in children. Among them hepatoblastoma (HB) is the most common. Aim: To report the results of the multidisciplinary management in 6 consecutive children: five HB and one metastatic Wilms tumor (MWT). Patients and methods: The mean age of patients was 42 months. All HB patients had elevated serum alfafetoprotein (median 150,000 ng/ml). All patients received preoperative chemotherapy: HB patients received carboplatin/doxorrubicin alternating with cisplatin, and the MWT patient, vincristine alone. Surgery included two formal right and two formal left hepatectomies, one extensive central resection with partial left segmentectomy, and one lateral segmentectomy. Extracorporeal circulation was used in the child with atrial involvement. All patients received postoperative chemotherapy. Results: All tumors had variable regresion on preoperative chemotherapy. Complete resection with negative margins was achieved in all patients. The degree of tumor necrosis on histology ranged from 60% to 90%. Alfafetoprotein levels fell to under 10 ng/ml in all HB cases, one to three months after surgery. All patients survive free of disease at a median follow up of 19 months. Conclusion: A multidisciplinary approach including the well timed used of chemotherapy and surgery is highly effective in the management of pediatric malignant tumors.
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dc.languagees
dc.publisherSociedad Médica de Santiago
dc.relation10.4067/S0034-98871999001100009
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceRevista médica de Chile v.127 n.11 1999
dc.subjectAlpha-fetoproteins
dc.subjectChemotherapy, adjuvant, Hepatectomy
dc.subjectHepatoblastoma
dc.titleManejo multidisciplinario de tumores hepáticos malignos en el niño: una experiencia nacional reciente


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