| dc.creator | Ulloa F,María Teresa | |
| dc.creator | Giglio M,María Soledad | |
| dc.creator | Porte T,Lorena | |
| dc.creator | Santa Cruz A,Adriana | |
| dc.creator | McNab M,Paul | |
| dc.creator | Fica C,Alberto | |
| dc.creator | Pinto C,María Eugenia | |
| dc.creator | Kawaguchi G,Keyko | |
| dc.creator | Carmi K,Alejandra | |
| dc.date | 2000-01-01 | |
| dc.date.accessioned | 2019-05-02T21:10:42Z | |
| dc.date.available | 2019-05-02T21:10:42Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0034-98872000000100004 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81044 | |
| dc.description | Background: The virulence of Streptococcus pyogenes is determined by a variety of structural molecules, toxins and complex enzymes. Pyrogenic exotoxins cause fever, erythematous reactions, cytotoxic and immunological effects. Aim: To assess the frequency of speA, speB and speC genes in Chilean Streptococcus pyogenes strains and their association with the invasiveness of infections. Material and methods: The genes for pyrogenic exotoxins SpeA, SpeB and SpeC were determined by polymerase chain reactions in 114 strains of group A Streptococcus pyogenes isolated from Chilean patients with invasive or non invasive infections. Results: The gene for SpeA was present in 30.7% of isolates, the gene for SpeB was present in 69.3% and the gen for SpeC in 44.7% of isolates. The gene for SpeA was present in 20 of 33 invasive infections and in 15 of 81 non invasive infections (p <0.0001). On the contrary, the gene for SpeC was present in 11 of 33 invasive infections and in 41 of 81 non invasive infections (p <0.05). The frequency of speB was similar in invasive and non invasive infections. Conclusions: There is a clear relationship between the presence of SpeA genes and the severity of infections caused by Streptococcus pyogenes. (Rev Méd Chile 2000; 128: 27-34) | |
| dc.format | text/html | |
| dc.language | es | |
| dc.publisher | Sociedad Médica de Santiago | |
| dc.relation | 10.4067/S0034-98872000000100004 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Revista médica de Chile v.128 n.1 2000 | |
| dc.subject | Exotoxins | |
| dc.subject | Gene frecuency | |
| dc.subject | Polymerase chain reaction | |
| dc.title | Detección de los genes de las exotoxinas pirogénicas SpeA, SpeB y SpeC en cepas chilenas de Streptococcus pyogenes y su asociación con la clínica | |
