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dc.creatorSOTO,CAROLINA R
dc.creatorARROYO,JORGE
dc.creatorALCAYAGA,JULIO
dc.date2002-01-01
dc.date.accessioned2019-05-02T21:21:07Z
dc.date.available2019-05-02T21:21:07Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602002000300010
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/81435
dc.descriptionAcetylcholine (ACh), adenosine 5'-triphosphate (ATP) and sodium cyanide (NaCN) activate petrosal ganglion (PG) neurons in vitro, and evoke ventilatory reflexes in situ, which are abolished after bilateral chemosensory denervation. Because in our previous experiments we superfused the isolated PG with solutions free of CO2 /HCO3¯ buffer, we studied its effects on the PG responses evoked in vitro. PGs from adult cats were superfused at a constant pH, with HEPES-supplemented (5 mM) saline with or without CO2 /HCO3¯ (5% / 26.2 mM) buffer, and carotid (sinus) nerve frequency discharge ( CN) recorded. Increases in CN evoked by ACh, ATP and NaCN in CO2-free saline were significantly reduced (P<0.05, Wilcoxon test) when CO2 / HCO3¯ was present in the superfusion medium. Thus, the presence of CO2 / HCO3¯ buffer appears to reduce PG neurons sensitivity to ACh, ATP and NaCN, an effect that may underlie the lack of ventilatory reflexes after bilateral chemodenervation
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602002000300010
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.35 n.3-4 2002
dc.subjectPetrosal Ganglion
dc.subjectCarotid sinus nerve
dc.subjectCarbon dioxide
dc.subjectBicarbonate
dc.subjectAcetylcholine
dc.subjectAdenosine 5'- triphosphate
dc.subjectCyanide
dc.titleEffects of bicarbonate buffer on acetylcholine-, adenosine 5´triphosphate-, and cyanide-induced responses in the cat petrosal ganglion in vitro


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