Show simple item record

dc.creatorRICHTER,HANS G
dc.creatorTORRES-FARFÁN,CLAUDIA
dc.creatorROJAS-GARCÍA,PEDRO P
dc.creatorCAMPINO,CARMEN
dc.creatorTORREALBA,FERNANDO
dc.creatorSERÓN-FERRÉ,MARÍA
dc.date2004-01-01
dc.date.accessioned2019-05-02T21:21:13Z
dc.date.available2019-05-02T21:21:13Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000100003
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/81491
dc.descriptionThe circadian time-keeping system ensures predictive adaptation of individuals to the reproducible 24-h day/night alternations of our planet by generating the 24-h (circadian) rhythms found in hormone release and cardiovascular, biophysical and behavioral functions, and others. In mammals, the master clock resides in the suprachiasmatic nucleus (SCN) of the hypothalamus. The molecular events determining the functional oscillation of the SCN neurons with a period of 24-h involve recurrent expression of several clock proteins that interact in complex transcription/translation feedback loops. In mammals, a glutamatergic monosynaptic pathway originating from the retina regulates the clock gene expression pattern in the SCN neurons, synchronizing them to the light:dark cycle. The emerging concept is that neural/humoral output signals from the SCN impinge upon peripheral clocks located in other areas of the brain, heart, lung, gastrointestinal tract, liver, kidney, fibroblasts, and most of the cell phenotypes, resulting in overt circadian rhythms in integrated physiological functions. Here we review the impact of day/night alternation on integrated physiology; the molecular mechanisms and input/output signaling pathways involved in SCN circadian function; the current concept of peripheral clocks; and the potential role of melatonin as a circadian neuroendocrine transducer
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602004000100003
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.37 n.1 2004
dc.subjectbiological rhythms
dc.subjectcircadian timing system
dc.subjectclock genes
dc.subjectmelatonin
dc.titleThe Circadian Timing System: Making Sense of day/night gene expression


This item appears in the following Collection(s)

Show simple item record