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dc.creatorPETERSEN,OLE H.
dc.date2004-01-01
dc.date.accessioned2019-05-02T21:21:21Z
dc.date.available2019-05-02T21:21:21Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602004000400023
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/81555
dc.descriptionThe pancreatic acinar unit is a classical example of a polarized tissue. Even in isolation, these cells retain their polarity, and this has made them particularly useful for Ca2+ signaling studies. In 1990, we discovered that this cell has the capability of producing both local cytosolic and global Ca2+ signals. The mechanisms underlying this signal generation have now been established. Furthermore, it has become clear that the local signals are sufficient for the control of both fluid and enzyme secretion, whereas prolonged global signals are dangerous and give rise to acute pancreatitis, a disease where the pancreas digests itself.
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dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602004000400023
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.37 n.4 2004
dc.subjectPancreatic Acinar Cell
dc.subjectIntracellular Communication
dc.subjectCa2+ Signal Compartmentalization
dc.subjectCa2+ Release Mechanisms
dc.subjectLocal Ca2+ Signals
dc.titleLocal and global Ca2+ signals: physiology and pathophysiology


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