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Effects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats

dc.creatorSAKURABA,SHIGEKI
dc.creatorKUWANA,SHUN-ICHI
dc.creatorERIKSSON,LARS I
dc.creatorOKADA,YASUMASA
dc.creatorOCHIAI,RYOICHI
dc.creatorKASHIWAGI,MASANORI
dc.creatorHATORI,EIKI
dc.creatorLINDAHL,STEN G. E.
dc.creatorTAKEDA,JUNZO
dc.date2005-01-01
dc.date.accessioned2019-05-02T21:21:25Z
dc.date.available2019-05-02T21:21:25Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200012
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/81593
dc.descriptionNeuromuscular blocking agents suppress central respiratory activity through their inhibitory effects on preinspiratory neurons and the synaptic drive from preinspiratory neurons to inspiratory neurons. Central CO2-chemosensitive areas, which partly consist of CO2-excited neurons, in the rostral ventrolateral medulla are thought to provide tonic drive to the central respiratory network and involve cholinergic mechanisms, which led us to hypothesize that neuromuscular blocking agents can inhibit CO2-excited neurons and attenuate respiratory CO2 responsiveness. To test this hypothesis, we used isolated brainstem-spinal cord preparations from newborn rats. The increase of C4 burst frequency induced by a hypercapnic superfusate, i.e. respiratory CO2 responsiveness, was suppressed by the application of neuromuscular blocking agents, either d-tubocurarine (10, 100μM) or vecuronium (100μM). These agents (40μM) also induced hyperpolarization and decreases in firing frequency of CO2-excited neurons in the rostral ventrolateral medulla. Our results demonstrate that neuromuscular blocking agents inhibit CO2-excited tonic firing neurons and attenuate respiratory CO2 responsiveness.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602005000200012
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.38 n.2-3 2005
dc.subjectbrainstem
dc.subjectchemosensitivity
dc.subjectCO2 responsiveness
dc.subjectmuscle relaxant
dc.subjectnicotinic acetylcholine
dc.titleEffects of neuromuscular blocking agents on central respiratory chemosensitivity in newborn rats


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