| dc.creator | LINHARES,JOSÉ JUVENAL | |
| dc.creator | GUERREIRO DA SILVA,ISMAEL DALE COTRIM | |
| dc.creator | NOGUEIRA DE SOUZA,NAIARA C | |
| dc.creator | COELHO NORONHA,EMMANUELLE | |
| dc.creator | FERRARO,ODAIR | |
| dc.creator | DE CARVALHO,CRISTINA VALLETA | |
| dc.creator | CHADA BARACAT,EDMUND | |
| dc.creator | FARAH BARACAT,FAUSTO | |
| dc.date | 2005-01-01 | |
| dc.date.accessioned | 2019-05-02T21:21:27Z | |
| dc.date.available | 2019-05-02T21:21:27Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000200017 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81598 | |
| dc.description | Due to the conflicting results regarding the association between breast cancerand the GSTM1 null mutation, our aim was to research this associationin a Brazilian population and correlations withsmoking, reproductive history and several clinical pathologies. A case-control study was performed on 105 women with breast cancer and 278 controls. Extraction of DNA was accomplished according to the protocol of the GFX® kit and polymorphism analysis by the PCR technique. The control and experimental groups were compared and statistical analysis assessed by X² or Fisher's exact test. The deletion in the GSTM1 gene in the breast cancer group had a prevalence of 32 (30.4%) individuals with the presence of null mutation. In the control group, the null mutation was present in 104 (37.4%) women. Upon comparison of the two groups, no statistically significant difference of the GSTM1 gene was observed, with an odds ratio (OR) of 0.74, 95%, confidence interval (CI) 0.45 - 1.20, p = 0.277. The results conclusively show that singlegene GSTM1 polymorphisms do not confer a substantial risk of breastcancer to its carriers. Furthermore, in this study no correlation was found between GSTs andsmoking, reproductive history and several clinical pathologies with respect to cancer risk. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602005000200017 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.38 n.2-3 2005 | |
| dc.subject | Breast cancer | |
| dc.subject | genetic polymorphisms | |
| dc.subject | GSTM1 | |
| dc.title | Genetic polymorphism of GSTM1 in women with breast cancer and interact with reproductive history and several clinical pathologies | |
