| dc.creator | OYARZÚN,MANUEL | |
| dc.creator | DUSSAUBAT,NELSON | |
| dc.creator | GONZÁLEZ,SERGIO | |
| dc.date | 2005-01-01 | |
| dc.date.accessioned | 2019-05-02T21:21:27Z | |
| dc.date.available | 2019-05-02T21:21:27Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602005000400007 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81608 | |
| dc.description | To study the effect of ozone in a chronically damaged lung, we used a bleomycin (BLM) induced pulmonary fibrosis model. Both endotracheal instillation of BLM and O3 exposure both produce lung inflammation and fibrosis. Oxidative stress would be a common mechanism of damage for both BLM and O3. Our aim was to assess lung injury induced by 5 and 60 days of intermittent exposure to 0.25 ppm O3 in rats with bleomycin-induced pulmonary fibrosis. Thirty-day-old Sprague Dawley rats were endotracheally instilled with BLM (1 U/100 g body weight) and, 30 days later, exposed to 0.25 ppm O3 (0.25 ppm 4 h per day, 5 days a week). Histopatology controls were instilled with saline and breathing room air. Histopathological evaluation of lungs was done 5 and 60 days after O3 exposure. BLM-induced lung damage did not change after 60 days of intermittent O3 exposure. Five days of O3 exposure increased the mean score of BLM-induced pulmonary inflammation and fibrosis (p=0.06). Frequency of bronchopneumonia increased from 1/7 to 6/6 (p <0.001), suggesting that a short-term exposure to O3 in a previously damaged lung might be a risk factor for developing further lung injury | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602005000400007 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.38 n.4 2005 | |
| dc.subject | bleomycin | |
| dc.subject | histopathology | |
| dc.subject | lung damage | |
| dc.subject | ozone exposure | |
| dc.title | Effect of 0.25 ppm Ozone exposure on pulmonary damage induced by bleomycin | |
