| dc.creator | ARACENA,PAULA | |
| dc.creator | AGUIRRE,PABLA | |
| dc.creator | MUÑOZ,PABLO | |
| dc.creator | NÚÑEZ,MARCO T | |
| dc.date | 2006-01-01 | |
| dc.date.accessioned | 2019-05-02T21:21:30Z | |
| dc.date.available | 2019-05-02T21:21:30Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602006000100017 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81629 | |
| dc.description | Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the cause of several forms of neurodegeneration. Here, we review recent evidence that gives support to the following notions: 1) neuronal iron accumulation leads to oxidative stress and cell death; 2) neuronal survival to iron accumulation associates with decreased expression of the iron import transporter DMT1 and increased expression of the efflux transporter IREG1; and 3) the adaptive process of neurons towards iron-induced oxidative stress includes a marked increase in both the expression of the catalytic subunit of gamma glutamate-cysteine ligase and glutathione. These findings may help to understand aging-related neurodegeneration hallmarks: oxidative damage, functional impairment and cell death. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602006000100017 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.39 n.1 2006 | |
| dc.subject | neurons | |
| dc.subject | iron metabolism | |
| dc.subject | iron accumulation | |
| dc.subject | oxidative stress | |
| dc.subject | glutathione metabolism | |
| dc.subject | neurodegeneration | |
| dc.title | Iron and glutathione at the crossroad of redox metabolism in neurons | |
