| dc.creator | ARANCIBIA,SERGIO A | |
| dc.creator | BELTRÁN,CAROLL J | |
| dc.creator | AGUIRRE,ISABEL M | |
| dc.creator | SILVA,PAULINA | |
| dc.creator | PERALTA,ALEXIS L | |
| dc.creator | MALINARICH,FRANO | |
| dc.creator | HERMOSO,MARCELA A | |
| dc.date | 2007-01-01 | |
| dc.date.accessioned | 2019-05-02T21:21:36Z | |
| dc.date.available | 2019-05-02T21:21:36Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200001 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81736 | |
| dc.description | During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602007000200001 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.40 n.2 2007 | |
| dc.subject | Toll-like receptors | |
| dc.subject | Innate Immunity | |
| dc.subject | cytokines | |
| dc.subject | MyD88 | |
| dc.subject | NFkB | |
| dc.title | Toll-like Receptors are Key Participants in Innate Immune Responses | |
