| dc.creator | LÓPEZ-ALARCÓN,CAMILO | |
| dc.creator | SPEISKY,HERNÁN | |
| dc.creator | LISSI,EDUARDO | |
| dc.date | 2007-01-01 | |
| dc.date.accessioned | 2019-05-02T21:21:37Z | |
| dc.date.available | 2019-05-02T21:21:37Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200006 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81745 | |
| dc.description | The antioxidant effect of 5-Aminosalicylic acid (5-ASA) on copper-mediated LDL oxidation was followed either by the emitted chemiluminiscence (CL) or by UV-vis spectroscopy. 5-ASA addition extends the lag phase in a concentration-dependent manner without changes in the rate of the process in the autoaccelerated phase. The antioxidant behavior of 5-ASA was very similar to that of Trolox, a very efficient water soluble antioxidant. The copper-binding capacity of 5-ASA was evaluated by UV-visible spectroscopy. The addition of copper to a 5-ASA solution increases the absorbance at 332 nm and generates a new band at 298 nm. These changes in the UV-vis spectra indicate formation of a complex between 5-ASA and copper. However, LDL protection by 5-ASA is unrelated to its copper chelating capacity | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602007000200006 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.40 n.2 2007 | |
| dc.subject | 5-Aminosalicylic acid | |
| dc.subject | Antioxidant | |
| dc.subject | LDL oxidation | |
| dc.title | Antioxidant effect of 5-amino salicylic acid on copper-mediated LDL oxidation | |
