| dc.creator | AVILA,ANA D | |
| dc.creator | CALDERÓN,CARLOS F | |
| dc.creator | PEREZ,RITA M | |
| dc.creator | PONS,CARMEN | |
| dc.creator | PEREDA,CELIA M | |
| dc.creator | ORTIZ,ANA R | |
| dc.date | 2007-01-01 | |
| dc.date.accessioned | 2019-05-02T21:21:37Z | |
| dc.date.available | 2019-05-02T21:21:37Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602007000200008 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81749 | |
| dc.description | Hybrid molecules obtained through conjugation of monoclonal antibodies and toxins constitute an approach under exploration to generate potential agents for the treatment of cancer and other diseases. A frequently employed toxic component in the construction of such immunotoxins is ricin, a plant toxin which inhibits protein synthesis at ribosomal level and so requires to be internalized by the cell. A hemolytic toxin isolated from the sea anemone Stichodactyla helianthus, which is active at the cell membrane level, was linked through a disulfide bond to the anti-epidermal growth factor receptor monoclonal antibody ior egf/r3. The resulting immunotoxin did not exhibit hemolytic activity except under reducing conditions. It was toxic for H125 cells that express the human epidermal growth factor receptor, but non-toxic for U1906 cells that do not express this receptor | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602007000200008 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.40 n.2 2007 | |
| dc.subject | Epidermal growth factor | |
| dc.subject | epidermal growth factor receptor | |
| dc.subject | hemolytic toxins | |
| dc.subject | immunotoxins | |
| dc.subject | monoclonal antibodies | |
| dc.title | Construction of an immunotoxin by linking a monoclonal antibody against the human epidermal growth factor receptor and a hemolytic toxin | |
