| dc.creator | ELIZONDO,ALEJANDRA | |
| dc.creator | ARAYA,JULIA | |
| dc.creator | RODRIGO,RAMÓN | |
| dc.creator | SIGNORINI,CINZIA | |
| dc.creator | SGHERRI,CRISTIANA | |
| dc.creator | COMPORTI,MARIO | |
| dc.creator | PONIACHIK,JAIME | |
| dc.creator | VIDELA,LUIS A | |
| dc.date | 2008-01-01 | |
| dc.date.accessioned | 2019-05-02T21:21:43Z | |
| dc.date.available | 2019-05-02T21:21:43Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000100008 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/81851 | |
| dc.description | Our aim was to study the influence of weight loss on the fatty acid (FA) composition of liver and erythrocyte phospholipids and oxidative stress status in obese, non-alcoholic, fatty liver disease (NAFLD) patients. Seven obese NAFLD patients who underwent subtotal gastrectomy with a gastro-jejunal anastomosis in roux and Y were studied immediately and 3 months after surgery. Seven non-obese patients who underwent anti-reflux surgery constituted the control group. Serum F2-isoprostane levels were measured by GS/NICI-MS/MS and FA composition was determined by GC. At the time of surgery, controls and obese patients exhibited a hepatic polyunsaturated fatty acid (PUFA) pattern that correlated with that of erythrocytes. Three months after surgery, NAFLD patients lost 21% of initial body weight; serum F2-isoprostane levels decreased by 76%; total PUFA, long-chain PUFA (LCPUFA), n-3 PUFA, and n-3 LCPUFA increased by 22, 29, 81, and 93%, respectively; n-6/n-3 LCPUFA ratio decreased by 51%; docosahexaenoic acid/docosapentaenoic acid ratio increased by 19-fold; and the n-3 product/precursor ratio (20: 5 + 22: 5 + 22: 6)/18: 3 increased by 164% (p<0.05). It is concluded that weight loss improves the n-3 LCPUFA status of obese patients in association with significant amelioration in the biomarkers of oxidative stress, membrane FA insaturation, and n-3 LCPUFA biosynthesis capacity, thus representing a central therapeutic issue in the improvement of obesity-related metabolic alterations involved in the mechanism of hepatic steatosis | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602008000100008 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.41 n.1 2008 | |
| dc.subject | polyunsaturated fatty acids | |
| dc.subject | oxidative stress | |
| dc.subject | obesity | |
| dc.subject | weight loss | |
| dc.title | Effects of weight loss on liver and erythrocyte polyunsaturated fatty acid pattern and oxidative stress status in obese patients with non-alcoholic fatty liver disease | |
