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dc.creatorCIFUENTES,MARIANA
dc.creatorALBALA,CECILIA
dc.creatorROJAS,CECILIA V
dc.date2008-01-01
dc.date.accessioned2019-05-02T21:21:44Z
dc.date.available2019-05-02T21:21:44Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602008000200009
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/81865
dc.descriptionIt has been proposed that differences in adipocyte function and/or metabolism between obese and lean individuáis may manifest themselves in functional adipose tissue abnormalities that lead to metabolic disorders in obesity. We studied lipogenesis and lipolysis of omental adipocytes from obese (OB) and non-obese (NOB) humans. The specific activity of the lipogenic marker enzyme G3PDH was 50% lower in total adipocytes of OB compared to that of NOB subjects. Omental adipocytes from OB subjects also had lower basal lipolytic levéis, and a lower lipolytic response to p-adrenergic stimulus. Cholesterol depletion of adipocyte plasma membrane using methyl β-cyclodextrin caused a lipolytic effect on adipocytes of both groups together, but when obese and lean subjects were analyzed separately, the response was significant only in the obese. We present evidence of a different lipogenic and lipolytic profile in obese individuáis' omental adipocytes, and propose a relevant role of plasma membrane cholesterol, where the impact of its removal in OB and NOB adipocyte lipolysis differs.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602008000200009
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.41 n.2 2008
dc.subjectadipocyte
dc.subjectcholesterol
dc.subjectlipogenesis
dc.subjectlipolysis
dc.subjectobesity
dc.subjecttriglyceride metabolism
dc.titleDifferences in lipogenesis and lipolysis in obese and non-obese adult human adipocytes


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