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dc.creatorAIYEGORO,OLAYINKA A
dc.creatorAFOLAYAN,ANTHONY J
dc.creatorOKOH,ANTHONY I
dc.date2009-01-01
dc.date.accessioned2019-05-02T21:21:50Z
dc.date.available2019-05-02T21:21:50Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000300007
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/81954
dc.descriptionThe effect of combinations of the crude methanolic extract of the leaves of Helichrysum pedunculatum and eight first-line antibiotics were investigated by time kill assays against a panel of bacterial strains that have been implicated in wound infections. The plant extract showed appreciable antibacterial activities against the test bacteria with zones of inhibition ranging between 18 and 27 mm, and minimum inhibitory concentrations (MICs) varying between 0.1 and 5.0 mg/ml. The MICs of the test antibiotics range between 0.001 and 0.412 mg/ml, and combination of the plant extract and the antibiotics resulted in reduction of bacterial counts by between 0 and 6.63 Log10 cfu/ml. At V2 MIC, 56.81% synergy; 43.19% indifference and no antagonism were observed, and at MIC levels, 55.68% synergy; 44.32% indifference and no antagonism were observed when the extracts were combined with eight different antibiotics. In all, 60% of the interactions were synergistic. All combination regimes on Staphylococcus aureus ATCC 6538 yielded no synergy, neither was antagonism detected in any of the assays. We propose that extracts of the leaves of Helichrysum pedunculatum could be of relevance in combination therapy and as a source of resistance modifying principies that could be useful as treatment options for persistent wound infections.
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dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602009000300007
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.42 n.3 2009
dc.subjectHelichrysum pedunculatum
dc.subjecttime kill assay
dc.subjectsynergism
dc.titleSynergistic interaction of Helichrysum pedunculatum leaf extracts with antibiotics against wound infection associated bacteria


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