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dc.creatorPETACCI,FERNANDO
dc.creatorFREITAS,SILVIA S
dc.creatorBRUNETTI,IGUATEMY L
dc.creatorKHALIL,NAJEH M
dc.date2010-01-01
dc.date.accessioned2019-05-02T21:21:53Z
dc.date.available2019-05-02T21:21:53Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000100008
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82011
dc.descriptionAstilbin (5,7,3 ,4 -tetrahydroxy-2,3-dihydroflavonol-3-ß-o-rhamnoside), a flavonoid with a large range of biological activities, was isolated from Dimorphandra mollis, a shrub common to the Brazilian Cerrado. The purpose of this study is to verify the effects of astilbin on myeloperoxidase (MPO) and horseradish peroxidase (HRP), and its antioxidant activity against hypochlorous acid (HOCl) and total antioxidant activity (TAC) by the 2,2 -azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) radical cation (ABTS +). Astilbin inhibited MPO and HRP activities in a concentration-dependent relationship and effectively scavenged HOCl. The TAC by ABTS + of astilbin (IC50 ~ 20 mM) was higher than that of uric acid, which was used as a positive control. These data demonstrate that astilbin is a potent antioxidant and that it inhibits MPO and HRP activities efficiently.
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dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602010000100008
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.43 n.1 2010
dc.subjectAstilbin
dc.subjectMyeloperoxidase
dc.subjectHorseradish peroxidase
dc.subjectReactive Oxygen Species
dc.subjectHypochlorous acid
dc.titleInhibition of peroxidase activity and scavenging of reactive oxygen species by astilbin isolated from Dimorphandra mollis (Fabaceae, Caesalpinioideae)


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