Show simple item record

dc.creatorVotto,Ana P. S
dc.creatorDomingues,Beatriz S
dc.creatorde Souza,Michele M
dc.creatorda Silva Júnior,Flavio M. R
dc.creatorCaldas,Sergiane S
dc.creatorFilgueira,Daza M. V. B
dc.creatorClementin,Rosilene M
dc.creatorPrimel,Ednei G
dc.creatorVallochi,Adriana L
dc.creatorFurlong,Eliana B
dc.creatorTrindade,Gilma S
dc.date2010-01-01
dc.date.accessioned2019-05-02T21:21:57Z
dc.date.available2019-05-02T21:21:57Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602010000400007
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82091
dc.descriptionOnion (Allium cepa) is being studied as a potential anticancer agent, but little is known regarding its effect in multidrug resistance (MDR) cells. In this work, the cytotoxicity of crude onion extract (OE) and fractioned extract (aqueous, methanolic and ethyl acetate), as well as some onion compounds (quercetin and propyl disulfide) were evaluated in Lucena MDR human erythroleukemic and its K562 parental cell line. The capacity of OE to induce apoptosis and/or necrosis in these cells, the possible participation of oxidative stress and DNA damage were also assessed. Similar sensitivities were obtained for both tumoral cells, however only OE caused significant effects in the cells. In K562 cells, a significant increase of apoptosis was verified while the Lucena cells experienced a significant increase of necrosis. An antioxidant capacity was verified for OE discarding oxidative damage. However, OE provoked similar significant DNA damage in both cell lines. Thus, the OE capacity to overcome the MDR phenotype suggests anti-MDR action of OE.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602010000400007
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.43 n.4 2010
dc.subjectantioxidant
dc.subjectapoptosis and/or necrosis
dc.subjectDNA damage
dc.subjectMDR phenotype
dc.subjectonion (Allium cepa)
dc.subjecttumoral cell
dc.titleToxicity mechanisms of onion (Allium cepa) extracts and compounds in multidrug resistant erythroleukemic cell line


This item appears in the following Collection(s)

Show simple item record