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dc.creatorStatti,Giancarlo A
dc.creatorConforti,Filomena
dc.creatorMenichini,Federica
dc.creatorMarrelli,Mariangela
dc.creatorGangale,Carmen
dc.creatorTundis,Rosa
dc.creatorLoizzo,Monica R
dc.creatorBonesi,Marco
dc.creatorMenichini,Francesco
dc.date2011-01-01
dc.date.accessioned2019-05-02T21:22:01Z
dc.date.available2019-05-02T21:22:01Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602011000300001
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82130
dc.descriptionThe present study shows for the first time the phenolic composition and the in vitro properties (antioxidant and inhibition of nitric oxide production) of Hypericum calabricum Sprengel collected in Italy. The content of hypericins (hypericin and pseudohypericin), hyperforin, flavonoids (rutin, hyperoside, isoquercetrin, quercitrin, quercetin and biapigenin) and chlorogenic acid of H. calabricum, have been determined. The ethyl acetate fraction from the aerial parts of H. calabricum exhibited activity against the radical 1,1-diphenyl-2-picrylhydrazyl (DPPH) with IC50 value of 1.6 jig/ml. The test for inhibition of nitric oxide (NO) production was performed using the murine monocytic macrophage cell line RAW 264.7. The ethyl acetate fraction had significant activity with an IC50 value of 102 jig/ml and this might indicate that it would have an anti-inflammatory effect in vivo.
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dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.4067/S0716-97602011000300001
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.44 n.3 2011
dc.subjectantiradical activity
dc.subjecthypericaceae
dc.subjectHypericum calabricum Sprengel
dc.subjectphenolic compounds
dc.titleProtective effect of Hypericum calabricum Sprengel on oxidative damage and its inhibition of nitric oxide in lipopolysaccharide-stimulated RAW 264.7 macrophages


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