dc.creator | Sinning,Mariana | |
dc.creator | Letelier,René | |
dc.creator | Rosas,Carlos | |
dc.creator | Fuenzalida,Marcela | |
dc.creator | Lemus,David | |
dc.date | 2012-01-01 | |
dc.date.accessioned | 2019-05-02T21:22:05Z | |
dc.date.available | 2019-05-02T21:22:05Z | |
dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200005 | |
dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82190 | |
dc.description | High-grade gliomas are highly vascularized tumors. Neo-angiogenesis plays a key role in tumor growth and resistance to therapy. A cerebrospinal fluid (CSF) sample could be a useful way to obtain pro-angiogenic predictive or prognostic markers at different stages of the disease. As a first step we looked for pro-angiogenic activity in the CSF of patients with high-grade gliomas. We performed the chicken embryo chorio-allantoic membrane (CAM) assay to study the angiogenic potential of the cerebrospinal fluid (CSF), obtained either by lumbar puncture (LP) or craniotomy from six patients with high-grade brain tumors (three glioblastoma (WHO grade IV), one anaplastic oligodendroglioma (WHO grade III), two anaplastic ganglioglioma (WHO grade III)), and four healthy controls. Significantly increased neo-angiogenesis was observed on the surface of the growing CAM in the 6 patients with high-grade gliomas compared to controls (3.69 ± 1.23 versus 2.16 ± 0.97 capillaries per area (mean ± SD), p<0.005). There was no statistical difference related to the hystological grade of the tumor (WHO grade III or IV), previous treatment (radio-chemotherapy plus temozolomide, temozolomide alone or no treatment), or the site of CSF sample (surgery or lumbar puncture). Our results suggest a pro-angiogenic potential in the CSF of patients with high-grade gliomas. | |
dc.format | text/html | |
dc.language | en | |
dc.publisher | Sociedad de Biología de Chile | |
dc.relation | 10.4067/S0716-97602012000200005 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.source | Biological Research v.45 n.2 2012 | |
dc.subject | angiogenesis | |
dc.subject | cerebrospinal fluid | |
dc.subject | glioblastoma | |
dc.subject | high-grade glioma | |
dc.title | Angiogenic potential of the cerebrospinal fluid (CSF) of patients with high-grade gliomas measured with the chick embryo chorioallantoic membrane assay (CAM) | |