| dc.creator | Ávalos,Ana María | |
| dc.creator | Apablaza,Felipe A | |
| dc.creator | Quiroz,Mariana | |
| dc.creator | Toledo,Viviana | |
| dc.creator | Peña,Juan Pedro | |
| dc.creator | Michea,Luis | |
| dc.creator | Irarrazabal,Carlos E | |
| dc.creator | Carrión,Flavio A | |
| dc.creator | Figueroa,Fernando E | |
| dc.date | 2012-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:06Z | |
| dc.date.available | 2019-05-02T21:22:06Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200012 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82203 | |
| dc.description | Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-β mRNA levels with no apparent change in IL-17 mRNA or protein levels in whole LV. Only TGF-β mRNA remained elevated at week 4 post-MI. However, further analysis revealed that IL-17A mRNA and protein levels as well as IL-6 and IL-23 mRNA were indeed increased in the infarcted region, though not in the remote non infarcted region of the LV, except for IL-23 mRNA. The increased expression of IL-17A and Th17-related cytokines in the infarcted region of LV, suggests that this proinflammatory pathway might play a role in early stages of post MI cardiac remodelling. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602012000200012 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.45 n.2 2012 | |
| dc.subject | Interleukin-17 | |
| dc.subject | Th17 | |
| dc.subject | myocardial infarction | |
| dc.subject | cardiovascular disease | |
| dc.title | IL-17A levels increase in the infarcted region of the left ventricle in a rat model of myocardial infarction | |
