| dc.creator | Reyes-Haro,Daniel | |
| dc.creator | Mora-Loyola,Ernesto | |
| dc.creator | Soria-Ortiz,Berenice | |
| dc.creator | García-Colunga,Jesús | |
| dc.date | 2013-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:09Z | |
| dc.date.available | 2019-05-02T21:22:09Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602013000100004 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82265 | |
| dc.description | Axons and glial cells are the main components of white matter. The corpus callosum (CC) is the largest white matter tract in mammals; in rodents, 99% of the cells correspond to glia after postnatal day 5 (P5). The area of the CC varies through life and regional differences related to the number of axons have been previously described. Whether glial cell density varies accordingly is unknown; thus the aim of this study was to estimate glial cell density for the genu, body and splenium -the three main regions of CC-, of P6 and P30 rats. Here we report that the density of CC glial cells reduced by ~10% from P6 to P30. Even so, the density of astrocytes showed a slight increase (+6%), probably due to differentiation of glioblasts. Interestingly, glial cell density decreased for the genu (-21%) and the body (-13%), while for the splenium a minor increase (+5%) was observed. The astrocyte/glia ratio increased (from P6 to P30) for the genu (+27%), body (+17%) and splenium (+4%). Together, our results showed regional differences in glial cell density of the CC. Whether this pattern is modified in some neuropathologies remains to be explored. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.4067/S0716-97602013000100004 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.46 n.1 2013 | |
| dc.subject | Astrocytes | |
| dc.subject | corpus callosum | |
| dc.subject | genu | |
| dc.subject | glial cells | |
| dc.subject | splenium | |
| dc.title | Regional density of glial cells in the rat corpus callosum | |
