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Assessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil

dc.creatorRamalho,Eduardo AVF
dc.creatorSilva-Filho,João LQ
dc.creatorCartaxo,Marina FS
dc.creatorCavalcanti,Carmelita BL
dc.creatorRêgo,Moacyr JBM
dc.creatorOliveira,Maria BM
dc.creatorBeltrão,Eduardo IC
dc.date2014-01-01
dc.date.accessioned2019-05-02T21:22:15Z
dc.date.available2019-05-02T21:22:15Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100003
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82363
dc.descriptionBACKGROUND: BRCA protein interacts with at least 13 different proteins that have been implicated with cancer susceptibility and loss of BRCA function is correlated to sensitivity to DNA crosslinking agents in preclinical models. RESULTS: BRCA2 methylation frequency was 44%, p53 Pro22 allele frequency was 32% and heterozygous frequency of Arg/Pro72 genotype was 60% which could be associated as risk factor for metastasis (p = 0.046 OR = 4.190). Regarding to polymorphism of codon 249 the frequency of Arg249 allele presented 82% which was considered not statistically significant. CONCLUSIONS: There was not statistical significance to BRCA2 promoter methylation with any parameters chosen. However, our findings suggest that patients who present heterozygous genotype at codon 72 of p53 gene may have a major susceptibility to any type of metastasis and this could serve as potential auxiliary biomarker for poor prognosis.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.1186/0717-6287-47-3
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.47 2014
dc.subjectBreast cancer
dc.subjectEpigenetics
dc.subjectMetastasis
dc.subjectMethylation
dc.subjectPolymorphism
dc.titleAssessment of changes in the brca2 and p53 genes in breast invasive ductal carcinoma in northeast Brazil


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