| dc.creator | Promphet,Porkaew | |
| dc.creator | Bunarsa,Sirirat | |
| dc.creator | Sutheerawattananonda,Manote | |
| dc.creator | Kunthalert,Duangkamol | |
| dc.date | 2014-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:16Z | |
| dc.date.available | 2019-05-02T21:22:16Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100015 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82375 | |
| dc.description | BACKGROUND: Declining immune function poses an important clinical challenge worldwide and supplementation with natural products that possessing immune enhancing properties is a promising approach for preventing or delaying immune function decline. Cocoons from yellow silkworms are a significant source of lutein, and this unexplored silk extract could be a viable alternative source for dietary lutein. This study assessed immunomodulatory activities of the silk lutein extract. Female BALB/c mice orally received lutein, either as silk or marigold extracts (10 or 20 mg/kg daily), or vehicle only (1% tween 80 in PBS pH 7.4) for 4 weeks. Natural killer (NK) cell activity, specific antibody production, lymphocyte subpopulations, mitogen-induced lymphocyte proliferation, and cytokine production were examined. RESULTS: Silk lutein extract increased NK cell activity, and the effect was dose-related whereas marigold lutein extract was ineffective. Silk lutein extract dose-dependently enhanced antibody production in pre-immunized mice but marigold lutein extract had no effect. Feeding with silk lutein extract increased the populations of CD3+ and CD4 + CD3 + cells. Silk lutein extract also stimulated concanavalin A- and lipopolysaccharide-induced proliferations of T and B lymphocytes, respectively. Moreover, silk lutein extract increased IL-2 and IFN-γ production while the effect of marigold lutein extract was undetectable. CONCLUSIONS: Together, silk lutein extract enhanced both innate and adaptive immune functions. This preparation may prove to be an effective supplement for strengthened immunity. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/0717-6287-47-15 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.47 2014 | |
| dc.subject | Antibody production | |
| dc.subject | BALB/c mice | |
| dc.subject | Immune function | |
| dc.subject | Interleukin-2 | |
| dc.subject | Natural killer cells | |
| dc.subject | Silk lutein extract | |
| dc.title | Immune enhancement activities of silk lutein extract from Bombyx mori cocoons | |
