| dc.creator | Soto-Urquieta,María G | |
| dc.creator | López-Briones,Sergio | |
| dc.creator | Pérez-Vázquez,Victoriano | |
| dc.creator | Saavedra-Molina,Alfredo | |
| dc.creator | González-Hernández,Gloria A | |
| dc.creator | Ramírez-Emiliano,Joel | |
| dc.date | 2014-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:22Z | |
| dc.date.available | 2019-05-02T21:22:22Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602014000100068 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82452 | |
| dc.description | BACKGROUND: Nitrosative and oxidative stress play a key role in obesity and diabetes-related mitochondrial dysfunction. The objective was to investigate the effect of curcumin treatment on state 3 and 4 oxygen consumption, nitric oxide (NO) synthesis, ATPase activity and lipid oxidation in mitochondria isolated from liver and kidneys of diabetic db/db mice. RESULTS: Hyperglycaemia increased oxygen consumption and decreased NO synthesis in liver mitochondria isolated from diabetic mice relative to the control mice. In kidney mitochondria, hyperglycaemia increased state 3 oxygen consumption and thiobarbituric acid-reactive substances (TBARS) levels in diabetic mice relative to control mice. Interestingly, treating db/db mice with curcumin improved or restored these parameters to normal levels; also curcumin increased liver mitochondrial ATPase activity in db/db mice relative to untreated db/db mice. CONCLUSIONS: These findings suggest that hyperglycaemia modifies oxygen consumption rate, NO synthesis and increases TBARS levels in mitochondria from the liver and kidneys of diabetic mice, whereas curcumin may have a protective role against these alterations. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/0717-6287-47-74 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.47 2014 | |
| dc.subject | Diabetes | |
| dc.subject | Mitochondria | |
| dc.subject | Curcumin | |
| dc.subject | ATPase activity | |
| dc.subject | Nitric oxide synthesis | |
| dc.subject | Lipid oxidation | |
| dc.title | Curcumin restores mitochondrial functions and decreases lipid peroxidation in liver and kidneys of diabetic db/db mice | |
