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TGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma

dc.creatorChen,Yijie
dc.creatorMa,Lin
dc.creatorHe,Qian
dc.creatorZhang,Shaobo
dc.creatorZhang,Chenghua
dc.creatorJia,Wei
dc.date2015-01-01
dc.date.accessioned2019-05-02T21:22:26Z
dc.date.available2019-05-02T21:22:26Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100026
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82518
dc.descriptionBACKGROUND: Transforming growth factor (TGF)-β is involved in many physiologic processes, it often promotes metastasis, and its high expression is correlated with poor prognosis. In the present study, we analyzed the correlation between transforming growth factor beta 1 (TGF-β1) expression and prognosis in intrahepatic cholangiocarcinoma RESULTS: We examined the expression of TGF-β 1 in 78 intrahepatic cholangiocarcinomas by immunohistochemistry and correlated the expression with clinicopathological parameters. TGF-β1 was expressed in 37 of 78 (47.4 %) intrahepatic cholangiocarcinomas. The expression of TGF-β 1 was significantly correlated with lymph node metastasis, distant metastasis, and tumour recurrence. Patients with TGFβ1-positive tumours had significantly shorter survival time. In a multivariant analysis, the expression of TGF-β1 and the tumour stage were independent prognostic factors CONCLUSIONS: Our data suggest that expression of TGF-β1 is a novel prognostic marker for intrahepatic cholangiocarcinoma
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.1186/S40659-015-0016-9
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.48 2015
dc.subjectIntrahepatic cholangiocarcinoma
dc.subjectTransforming growth factor beta 1 (TGFβ-1)
dc.subjectPrognosis
dc.titleTGF-β1 expression is associated with invasion and metastasis of intrahepatic cholangiocarcinoma


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