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dc.creatorCai,Guilan
dc.creatorQiao,Shanshan
dc.creatorChen,Kui
dc.date2015-01-01
dc.date.accessioned2019-05-02T21:22:28Z
dc.date.available2019-05-02T21:22:28Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100037
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82549
dc.descriptionBACKGROUND: Gliomas are the most common primary tumors in the central nervous system. Due to complicated signaling pathways involved in glioma progression, effective targets for treatment and biomarkers for prognosis prediction are still scant. RESULTS: In this study we revealed that a new microRNA (miR), the miR-221, was highly expressed in the glioma cells, and suppression of miR-221 resulted in decreased cellular proliferation, migration, and invasion in glioma cells. Mechanistic experiments validated that miR-221 participates in regulating glioma cells proliferation and invasion via suppression of a direct target gene, the Semaphorin 3B (SEMA3B). The rescue experiment with miR-221 and SEMA3B both knockdown results in significant reversion of miR-221 induced phenotypes. CONCLUSION: Taken together, our findings highlight an unappreciated role for miR-221 and SEMA3B in glioma.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.1186/S40659-015-0030-Y
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.48 2015
dc.subjectmiR-221
dc.subjectGlioma
dc.subjectSEMA3B
dc.subjectCancer metastasis
dc.titleSuppression of miR-221 inhibits glioma cells proliferation and invasion via targeting SEMA3B


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