| dc.creator | Guo,Jian-Ru | |
| dc.creator | Chen,Qian-Qian | |
| dc.creator | Lam,Christopher Wai-Kei | |
| dc.creator | Zhang,Wei | |
| dc.date | 2015-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:28Z | |
| dc.date.available | 2019-05-02T21:22:28Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100040 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82555 | |
| dc.description | BACKGROUND: We have investigated the potential anticancer effects of karanjin, a principal furanoflavonol constituent of the Chinese medicine Fordia cauliflora, using cytotoxic assay, cell cycle arrest, and induction of apoptosis in three human cancer cell lines (A549, HepG2 and HL-60 cells). RESULTS: MTT cytotoxic assay showed that karanjin could inhibit the proliferation and viability of all three cancer cells. The induction of cell cycle arrest was observed via a PI (propidium iodide)/RNase Staining Buffer detection kit and analyzed by flow cytometry: karanjin could dose-dependently induce cell cycle arrest at G2/M phase in the three cell lines. Cell apoptosis was assessed by Annexin V-FITC/PI staining: all three cancer cells treated with karanjin exhibited significantly increased apoptotic rates, especially in the percentage of late apoptosis cells. CONCLUSION: Karanjin can induce cancer cell death through cell cycle arrest and enhance apoptosis. This compound may be effective clinically for cancer pharmacotherapy. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/S40659-015-0031-X | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.48 2015 | |
| dc.subject | Karanjin | |
| dc.subject | Cell cycle | |
| dc.subject | Apoptosis | |
| dc.subject | Cancer therapy | |
| dc.title | Effects of karanjin on cell cycle arrest and apoptosis in human A549, HepG2 and HL-60 cancer cells | |
