| dc.creator | Takahashi,Hiroshi | |
| dc.creator | Ikeda,Kazuhiko | |
| dc.creator | Ogawa,Kazuei | |
| dc.creator | Saito,Syunnichi | |
| dc.creator | Ngoma,Alain M | |
| dc.creator | Mashimo,Yumiko | |
| dc.creator | Ueda,Koki | |
| dc.creator | Furukawa,Miki | |
| dc.creator | Shichishima-Nakamura,Akiko | |
| dc.creator | Ohkawara,Hiroshi | |
| dc.creator | Nollet,Kenneth E | |
| dc.creator | Ohto,Hitoshi | |
| dc.creator | Takeishi,Yasuchika | |
| dc.date | 2015-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:28Z | |
| dc.date.available | 2019-05-02T21:22:28Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100041 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82557 | |
| dc.description | BACKGROUND: CD4+CD25highFOXP3+ regulatory T (Treg) cells, which include thymus-derived and peripherally induced cells, play a central role in immune regulation, and are therefore crucial to prevent graft-versus-host disease (GVHD). The increasing use of allogeneic hematopoietic stem cell transplantation (allo-HSCT) for elderly patients with thymus regression, and our case of allo-HSCT shortly after total thymectomy, raised questions about the activity of thymus-derived Treg cells and peripherally induced Treg cells, which are otherwise indistinguishable. RESULTS: We found that despite pre-transplant thymectomy or older age, both naïve and effector Treg cells, as well as naïve and effector conventional T cells, proliferated in allo-HSCT recipients. Higher proportions of total Treg cells 1 month post allo-HSCT, and naïve Treg cells 1 year post allo-HSCT, appeared in patients achieving complete chimera without developing significant chronic GVHD, including our thymectomized patient, compared with patients who developed chronic GVHD. CONCLUSIONS: Treg cells that modulate human allogeneic immunity may arise peripherally as well as in the thymus of allo-HSCT recipients. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/S40659-015-0033-8 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.48 2015 | |
| dc.subject | Regulatory T cells | |
| dc.subject | Allogeneic hematopoietic stem cell transplantation | |
| dc.subject | Thymus | |
| dc.subject | Graft-versus-host disease | |
| dc.title | CD4+ T cells in aged or thymectomized recipients of allogeneic stem cell transplantations | |
