| dc.creator | Yang,Zhao | |
| dc.creator | Zhuan,Bing | |
| dc.creator | Yan,Ying | |
| dc.creator | Jiang,Simin | |
| dc.creator | Wang,Tao | |
| dc.date | 2015-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:29Z | |
| dc.date.available | 2019-05-02T21:22:29Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100047 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82567 | |
| dc.description | BACKGROUND: Although numerous efforts have been made, the pathogenesis underlying lung squamous-cell carcinoma (SCC) remains unclear. This study aimed to identify the CNV-driven genes by an integrated analysis of both the gene differential expression and copy number variation (CNV). RESULTS: A higher burden of the CNVs was found in 10-50 kb length. The 16 CNV-driven genes mainly located in chr 1 and chr 3 were enriched in immune response [e.g. complement factor H (CFH) and Fc fragment of IgG, low affinity Ilia, receptor (FCGR3A)], starch and sucrose metabolism [e.g. amylase alpha 2A (AMY2A)]. Furthermore, 38 TFs were screened for the 9 CNV-driven genes and then the regulatory network was constructed, in which the GATA-binding factor 1, 2, and 3 (GATA 1, GATA2, GATA3) jointly regulated the expression of TP63. CONCLUSIONS: The above CNV-driven genes might be potential contributors to the development of lung SCC. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/S40659-015-0038-3 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.48 2015 | |
| dc.subject | Lung squamous-cell carcinoma | |
| dc.subject | Differentially expressed genes | |
| dc.subject | Copy number variation | |
| dc.subject | Copy number variation-driven genes | |
| dc.title | Integrated analyses of copy number variations and gene differential expression in lung squamous-cell carcinoma | |
