dc.creator | Xu,Yuan-kun | |
dc.creator | Ke,Yan | |
dc.creator | Wang,Bin | |
dc.creator | Lin,Jian-hao | |
dc.date | 2015-01-01 | |
dc.date.accessioned | 2019-05-02T21:22:31Z | |
dc.date.available | 2019-05-02T21:22:31Z | |
dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602015000100064 | |
dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82600 | |
dc.description | BACKGROUND: Osteoarthritis (OA) is a common arthritic disease and multifactorial whole-joint disease. Interactions of chemokines and OA is inadequately documented RESULTS: In vivo and in vitro studies were conducted to investigate monocyte chemoattractant protein 1 (MCP-1) and receptor chemokine (C-C motif) receptor 2 (CCR2) in chondrocyte degradation and cartilage degeneration. Chondrocytes from 16 OA patients and 6 normal controls were involved in this study. After stimulation of MCP-1, the expression of MCP-1 and CCR2 increased significantly (P < 0.001) and the expression of MMP-13 also increased (P < 0.05). MCP-1 stimulation also induced (or enhanced) the apoptosis of OA chondrocytes (P < 0.05). Additionally, the degradation of cartilage matrix markers (metalloproteinase 3 and 13, MMP3 and MMP13) in the culture medium of normal chondrocytes was also assessed. Furthermore, intra-articular injection of MCP-1 in mouse knees induced cartilage degradation and the CCR2 antagonist did not impede cartilage destroy in rats knees of monosodium iodoacetate (MIA) model CONCLUSIONS: The results of this study demonstrate that the MCP-1-CCR2 ligand-receptor axis plays a special role in the initiation and progression of OA pathology. Patients with ambiguous etiology can gain some insight from the MCP-1-CCR2 ligand-receptor axis | |
dc.format | text/html | |
dc.language | en | |
dc.publisher | Sociedad de Biología de Chile | |
dc.relation | 10.1186/S40659-015-0057-0 | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.source | Biological Research v.48 2015 | |
dc.subject | MCP-1 | |
dc.subject | CCR2 | |
dc.subject | Osteoarthritis | |
dc.subject | Chondrocyte | |
dc.subject | Rat | |
dc.subject | Mouse | |
dc.title | The role of MCP-1-CCR2 ligand-receptor axis in chondrocyte degradation and disease progress in knee osteoarthritis | |