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dc.creatorSalazar,Claudia
dc.creatorValdivia,Gonzalo
dc.creatorArdiles,Álvaro O.
dc.creatorEwer,John
dc.creatorPalacios,Adrian G.
dc.date2016-01-01
dc.date.accessioned2019-05-02T21:22:32Z
dc.date.available2019-05-02T21:22:32Z
dc.identifierhttps://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100014
dc.identifier.urihttp://revistaschilenas.uchile.cl/handle/2250/82619
dc.descriptionThe use of transgenic models for the study of neurodegenerative diseases has made valuable contributions to the field. However, some important limitations, including protein overexpression and general systemic compensation for the missing genes, has caused researchers to seek natural models that show the main biomarkers of neurodegenerative diseases during aging. Here we review some of these models-most of them rodents, focusing especially on the genetic variations in biomarkers for Alzheimer diseases, in order to explain their relationships with variants associated with the occurrence of the disease in humans.
dc.formattext/html
dc.languageen
dc.publisherSociedad de Biología de Chile
dc.relation10.1186/s40659-016-0072-9
dc.rightsinfo:eu-repo/semantics/openAccess
dc.sourceBiological Research v.49 2016
dc.subjectDegus
dc.subjectGenome
dc.subjectAPP
dc.subjectAPOE
dc.titleGenetic variants associated with neurodegenerative Alzheimer disease in natural models


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