| dc.creator | Hwan-Hee,Jang | |
| dc.creator | Su-Yeon,Cho | |
| dc.creator | Mi-Ju,Kim | |
| dc.creator | Jung-Bong,Kim | |
| dc.creator | Sung-Hyen,Lee | |
| dc.creator | Mee-Young,Lee | |
| dc.creator | Young-Min,Lee | |
| dc.date | 2016-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:36Z | |
| dc.date.available | 2019-05-02T21:22:36Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100041 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82671 | |
| dc.description | BACKGROUND: Asthma is an increasing global health problem, and novel strategies to prevent or ameliorate the condition are needed. Here, the effects of 80 % ethanol extracts of Salvia plebeia R. Br. (SE) on an induced inflammatory response were investigated RESULTS: Salvia plebeia R. Br. inhibited production of pro-inflammatory cytokines, such as TNF-α and IL-6, as well as nitric oxide (NO) in LPS-stimulated RAW 264.7 cells. NO and pro-inflammatory cytokine production was suppressed more effectively by SE of the aerial parts (SE-A) than of the roots (SE-R) of S. plebeia. In BEAS-2B cells, both SE-A and SE-R inhibited the increase in production of the inflammatory cytokines IL-6 and IL-8. We also investigated the antiasthmatic effects of SE in an ovalbumin (OVA)-induced BALB/c mouse model. SE-A treatment significantly reduced the number of airway eosinophils, IL-4 and IL-13 levels, mucus production, and inflammatory infiltration, as compared with the corresponding levels in the untreated, OVA-induced mice, and had similar effects to dexamethasone CONCLUSIONS: Salvia plebeia ethanol extract ameliorated the induced inflammatory response in RAW 264.7 and BEAS-2B cells, with more effective inhibition noted for SE-A than for SE-R. SE-A treatment was effective in improving the histopathological changes in the lungs of asthma model mice via modulation of eosinophils and Th2 cytokines. These results suggest that SE-A can be considered as a therapeutic agent that can potentially relieve asthma | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/s40659-016-0102-7 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.49 2016 | |
| dc.subject | Anti-inflammatory | |
| dc.subject | Asthma | |
| dc.subject | Salvia plebeia | |
| dc.title | Anti-inflammatory effects of Salvia plebeia R. Br extract in vitro and in ovalbumin-induced mouse model | |
