| dc.creator | Du,Guankui | |
| dc.creator | Xiao,Man | |
| dc.creator | Zhang,Xuezi | |
| dc.creator | Wen,Maoyu | |
| dc.creator | Pang,Chi | |
| dc.creator | Jiang,Shangfei | |
| dc.creator | Sang,Shenggang | |
| dc.creator | Xie,Yiqiang | |
| dc.date | 2017-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:37Z | |
| dc.date.available | 2019-05-02T21:22:37Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100206 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82687 | |
| dc.description | Abstract Background A number of dysregulated miRNAs have been identified and are proposed to have significant roles in the pathogenesis of type 2 diabetes mellitus or renal pathology. Alpinia oxyphylla has shown significant anti-inflammatory properties and play an anti-diabetes role. The objective of this study was to detect the alteration of miRNAs underlying the anti-diabetes effects of A. oxyphylla extract (AOE) in a type II diabetic animal model (C57BIKsj db-/db-). Results Treatment with AOE for 8 weeks led to lower concentrations of blood glucose, urine albumin, and urine creatinine. 17 and 13 miRNAs were statistically identified as differentially regulated in the DB/DB and db-/db- AOE mice, respectively, compared to the untreated db-/db- mice. Of these, 7 miRNAs were identified in both comparison groups, and these 7 miRNAs were verified by quantitative real-time PCR. Functional bioinformatics showed that the putative target genes of 7 miRNAs were associated with several diabetes effects and signaling pathways. Conclusions These founding suggest that the potential of AOE as a medicinal anti-diabetes treatment through changes in the expressions of specific miRNAs. The results provide a useful resource for future investigation of the role of AOE-regulated miRNAs in diabetes mellitus. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/s40659-017-0111-1 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.50 2017 | |
| dc.subject | miRNA | |
| dc.subject | db-/db- mice | |
| dc.subject | Alpinia oxyphylla Miq | |
| dc.subject | Kidney | |
| dc.subject | Diabetic nephropathy | |
| dc.title | Alpinia oxyphylla Miq. extract changes miRNA expression profiles in db-/db- mouse kidney | |
