| dc.creator | Shen,Xiaogang | |
| dc.creator | Bai,Yifeng | |
| dc.creator | Luo,Bin | |
| dc.creator | Zhou,Xiaogang | |
| dc.date | 2017-01-01 | |
| dc.date.accessioned | 2019-05-02T21:22:39Z | |
| dc.date.available | 2019-05-02T21:22:39Z | |
| dc.identifier | https://scielo.conicyt.cl/scielo.php?script=sci_arttext&pid=S0716-97602017000100223 | |
| dc.identifier.uri | http://revistaschilenas.uchile.cl/handle/2250/82720 | |
| dc.description | Abstract Background Growing evidence has supported that long non-coding RNAs (lncRNAs) could play vital roles in the development, progression, and prognosis of colorectal cancer (CRC). However, little is known about the clinical significance of BRAF-activated non-coding RNA (BANCR) in CRC. The aim of this study is to explore the clinical value of lncRNA BANCR in CRC patients. Methods The expression of lncRNA BANCR was measured in 106 CRC tissues and 65 adjacent normal tissues using the quantitative real-time PCR. Results The study showed that lncRNA BANCR was highly expressed in CRC tissues compared with adjacent normal tissues (P < 0.001). In addition, high expression of lncRNA BANCR was positively correlated with the lymph node metastasis (P < 0.001). Kaplan–Meier analysis showed that patients with high lncRNA BANCR expression had a shorter overall survival (OS) compared with the low lncRNA BANCR expression group (P = 0.001). Interestingly, for the group of patients with the lymph node metastasis, we found the similar result that high lncRNA BANCR expression was related to poor OS (P = 0.004). Furthermore, the multivariate Cox regression model analysis indicated that high expression of lncRNA BANCR was an independent poor prognostic factor in CRC patients (HR 2.24, 95% CI 1.22–4.16, P = 0.009). Conclusions Upregulation of lncRNA BANCR may be associated with the lymph node metastasis and poor survival of CRC. LncRNA BANCR could be served as a novel and useful biomarker for CRC lymph node metastasis and prognosis. | |
| dc.format | text/html | |
| dc.language | en | |
| dc.publisher | Sociedad de Biología de Chile | |
| dc.relation | 10.1186/s40659-017-0136-5 | |
| dc.rights | info:eu-repo/semantics/openAccess | |
| dc.source | Biological Research v.50 2017 | |
| dc.subject | lncRNA | |
| dc.subject | BANCR | |
| dc.subject | Colorectal cancer | |
| dc.subject | Lymph node metastasis | |
| dc.subject | Prognosis | |
| dc.title | Upregulation of lncRNA BANCR associated with the lymph node metastasis and poor prognosis in colorectal cancer | |
